Orta Doğu Teknik Üniversitesi, Sağlık ve Rehberlik Merkezi, Ankara

Keywords: Bone, Metal, Tissue Response.


In this review article, concepts on hard tissue-implant interactions are discussed and new concepts on bone and metal interaction are summarized. Materials inserted into living bodies can cause local or systemic adverse reactions though they are known as inert and biocompatible. The aim of this article was to review recent advancements on metals and their effects on bone tissue. The spectrum of effects of metals on bone tissue is between non specific immunogenic reactions to carcinogenesis. Side effects of metal particles are not only local. Migrating particles may cause systemic side effects. Ion implantation and surface coatings are currently used to prevent corrosion and improve the biocompatibility of metal implants. Surface modification of implant is used to improve the stabilization in bone tissue. Though widely used in orthopedic and trauma surgery, ideal metals are under investigation. Better alloys and coatings, some of biological origin, will probably shape the future of orthopedic implants. A decrease in metal use and increase in biological origin implants will shape the future.